Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• Автори: Nhu Truong (Автор), Andrea L. Cottingham (Автор), Shruti Dharmaraj (Автор), Jacob R. Shaw (Автор), Jackline Joy Martin Lasola (Автор), Christopher C. Goodis (Автор), Steven Fletcher (Автор), Ryan M. Pearson (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2024-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...