Non-<i>β</i>-Lactam Allosteric Inhibitors Target Methicillin-Resistant <i>Staphylococcus aureus</i>: An <i>In Silico</i> Drug Discovery Study

• Main Authors: Mahmoud A. A. Ibrahim (Author), Khlood A. A. Abdeljawaad (Author), Alaa H. M. Abdelrahman (Author), Othman R. Alzahrani (Author), Fahad M. Alshabrmi (Author), Esraa Khalaf (Author), Mahmoud F. Moustafa (Author), Faris Alrumaihi (Author), Khaled S. Allemailem (Author), Mahmoud E. S. Soliman (Author), Paul W. Paré (Author), Mohamed-Elamir F. Hegazy (Author), Mohamed A. M. Atia (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Penicillin-binding proteins (PBPs) catalyze the final stages for peptidoglycan cell-wall bio-synthesis. Mutations in the PBP2a subunit can attenuate <i>β</i>-lactam antibiotic activity, resulting in unimpeded cell-wall formation and methicillin-resistant <i>Staphylococcus aureus<...