Osteopontin neutralization increases vitamin D receptors on NKT cells and ameliorates liver fibrosis by promoting their activity

• Main Authors: Johnny Amer (Author), Ahmad Salhab (Author), Enas Hussini (Author), Rasha Shweiki (Author), Iman Zahran (Author), Mohammad Far (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction and AimsVitamin D has an immunomodulatory property influencing the activity of NKT cells. We aimed to study the impact of osteopontin (OPN), a key driver of fibrosis, on NKT cells' vitamin D receptor (VDR) and activity alterations.MethodsLiver fibrosis was induced in BALB/C mice wi...