FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy

• Main Authors: Shaoxing Guan (Author), Xi Chen (Author), Youhao Chen (Author), Guohui Wan (Author), Qibiao Su (Author), Heng Liang (Author), Yunpeng Yang (Author), Wenfeng Fang (Author), Yan Huang (Author), Hongyun Zhao (Author), Wei Zhuang (Author), Shu Liu (Author), Fei Wang (Author), Wei Feng (Author), Xiaoxu Zhang (Author), Min Huang (Author), Xueding Wang (Author), Li Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatotoxicity is a common side effect for patients treated with gefitinib, but the related pathogenesis is unclear and lacks effective predictor and management strategies. A multi-omics approach integrating pharmacometabolomics, pharmacokinetics and pharmacogenomics was employed in non-small cell l...