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First total synthesis, antitumor evaluation and target identification of mornaphthoate E: A new tubulin inhibitor template acting on PI3K/Akt signaling pathway

Mornaphthoate E (MPE) is a prenylated naphthoic acid methyl ester isolated from the roots of a famous Chinese medicinal plant Morinda officinalis and shows remarkable cytotoxicity against several human tumor cell lines. In the current project, the first total synthesis of (±)-MPE was achieved in sev...

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Main Authors: Peipei Shan (Author), Tao Ye (Author), Ying-De Tang (Author), Hui Song (Author), Chao Wang (Author), Kongkai Zhu (Author), Feifei Yang (Author), Shi-Lei Zhang (Author), Pei-Wen Su (Author), Shuanhu Gao (Author), Hua Zhang (Author)
Format: Book
Published: Elsevier, 2024-05-01T00:00:00Z.
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