Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin

• Main Authors: Tamègnon Victorien Dougnon (Author), Honoré Sourou Bankolé (Author), Jean Robert Klotoé (Author), Maximin Sènou (Author), Lauris Fah (Author), Hornel Koudokpon (Author), Casimir Akpovi (Author), Tossou Jacques Dougnon (Author), Phyllis Addo (Author), Frédéric Loko (Author), Michel Boko (Author)
• Format: Book
• Published: Mashhad University of Medical Sciences, 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objective: Hypercholesterolemia is the greatest risk factor for cardiovascular diseases. The present study is conducted to evaluate the lipid lowering activity of leaves and fruits of Solanum macrocarpon, a vegetable, on Wistar rats experimentally rendered hypercholesterolemic by Triton X-100. Materials and Methods: The leaves and fruits were administered (p.o.) for 7 days to rats at doses of 400 and 800 mg/kg of body weight. Atorvastatin was used as reference treatment drug. The data were analyzed by the Brown-Forsythe ANOVA, Dunnett's T3 multiple comparison test, and Dunnett's t test. All tests were done at the 5% significance level. Results: Administration of S. macrocarpon (fruits as well as leaves) resulted in a statistically significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol, and triglycerides in the treated groups compared with the untreated hypercholesterolemic group, regardless of the administrated doses. A significant increase in HDL-cholesterol was observed in the treated groups. Hepatic disorders due to the Triton have been corrected by S. macrocarpon. Conclusions: This vegetable effectively suppresses experimental hypercholesterolemia in Wistar rats, suggesting a protective role in cardiovascular diseases. Its use by individuals at risk should be promoted.

Item Description

2228-7930
2228-7949