Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
Hydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H<sub>2</sub>S in DNA repair has been identified, where H<sub>2</sub>S modulates cell cycle checkpoint responses, the DNA dam...
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| Main Authors: | , , , |
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| Format: | Book |
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MDPI AG,
2021-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Hydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter that exerts numerous physiologic and pathophysiologic effects. Recently, a role for H<sub>2</sub>S in DNA repair has been identified, where H<sub>2</sub>S modulates cell cycle checkpoint responses, the DNA damage response (DDR), and mitochondrial and nuclear genomic stability. In addition, several DNA repair proteins modulate cellular H<sub>2</sub>S concentrations and cellular sulfur metabolism and, in turn, are regulated by cellular H<sub>2</sub>S concentrations. Many DDR proteins are now pharmacologically inhibited in targeted cancer therapies. As H<sub>2</sub>S and the enzymes that synthesize it are increased in many human malignancies, it is likely that H<sub>2</sub>S synthesis inhibition by these therapies is an underappreciated aspect of these cancer treatments. Moreover, both H<sub>2</sub>S and DDR protein activities in cancer and cardiovascular diseases are becoming increasingly apparent, implicating a DDR-H<sub>2</sub>S signaling axis in these pathophysiologic processes. Taken together, H<sub>2</sub>S and DNA repair likely play a central and presently poorly understood role in both normal cellular function and a wide array of human pathophysiologic processes. Here, we review the role of H<sub>2</sub>S in DNA repair. |
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| Item Description: | 10.3390/antiox10111820 2076-3921 |