Bio‐functional hydrogel with antibacterial and anti‐inflammatory dual properties to combat with burn wound infection

• Main Authors: Yahui Xiong (Author), Yingbin Xu (Author), Fei Zhou (Author), Yanke Hu (Author), Jingling Zhao (Author), Zhonghua Liu (Author), Qiyi Zhai (Author), Shaohai Qi (Author), Zhaoqiang Zhang (Author), Lei Chen (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Abstract Burn infection delays wound healing and increases the burn patient mortality. Consequently, a new dressing with antibacterial and anti‐inflammatory dual properties is urgently required for wound healing. In this study, we propose a combination of methacrylate gelatin (GelMA) hydrogel system with silver nanoparticles embed in γ‐cyclodextrin metal-organic frameworks (Ag@MOF) and hyaluronic acid‐epigallocatechin gallate (HA‐E) for the burn wound infection treatment. Ag@MOF is used as an antibacterial agent and epigallocatechin gallate (EGCG) has exhibited biological properties of anti‐inflammation and antibacterial. The GelMA/HA‐E/Ag@MOF hydrogel enjoys suitable physical properties and sustained release of Ag+. Meanwhile, the hydrogel has excellent biocompatibility and could promote macrophage polarization from M1 to M2. In vivo wound healing evaluations further demonstrate that the GelMA/HA‐E/Ag@MOF hydrogel reduces the number of the bacterium efficiently, accelerates wound healing, promotes early angiogenesis, and regulates immune reaction. A further evaluation indicates that the noncanonical Wnt signal pathway is significantly activated in the GelMA/HA‐E/Ag@MOF hydrogel treated group. In conclusion, the GelMA/HA‐E/Ag@MOF hydrogel could serve as a promising multifunctional dressing for the burn wound healing.

Item Description

2380-6761
10.1002/btm2.10373