In Vitro Microbiological and Drug Release of Silver/Ibuprofen Loaded Wound Dressing Designed for the Treatment of Chronically Infected Painful Wounds

• Váldodahkkit: Alejandra Mogrovejo-Valdivia (Dahkki), Mickael Maton (Dahkki), Maria Jose Garcia-Fernandez (Dahkki), Nicolas Tabary (Dahkki), Feng Chai (Dahkki), Christel Neut (Dahkki), Bernard Martel (Dahkki), Nicolas Blanchemain (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2021-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Čoahkkáigeassu

This study consisted of developing a dressing loaded with silver (Ag) and ibuprofen (IBU) that provides a dual therapy, antibacterial and antalgic, intended for infected painful wounds. Therefore, non-woven polyethyleneterephtalate (PET) textiles nonwovens were pre-treated by cyclodextrin crosslinked with citric acid by a pad/dry/cure process. Then, textiles were impregnated in silver solution followed by a thermal treatment and were then coated by Layer-by-Layer (L-<i>b</i>-L) deposition of a polyelectrolyte multilayer (PEM) system consisting of anionic water-soluble poly(betacyclodextrin citrate) (PCD) and cationic chitosan. Finally, ibuprofen lysinate (IBU-L) was loaded on the PEM coating. We demonstrated the complexation of IBU with native βCD and PCD by phase solubility diagram and ¹H NMR. PEM system allowed complete IBU-L release in 6 h in PBS pH 7.4 batch (USP IV). On the other hand, microbiological tests demonstrated that loaded silver induced bacterial reduction of 4 Log₁₀ against <i>S. aureus</i> and <i>E. coli</i> and tests revealed that ibuprofen lysinate loading did not interfere with the antibacterial properties of the dressing.

Fuomášahttimat

10.3390/antibiotics10070805
2079-6382