A Double Blind Immunohistological Study Of The Effect Of Topical Tretinoin On Photoaged Skin
Fifteen very fair women with mild to moderate photoaging in there 60â€s were tested by doubled blind immunohistological study. Tretinoin 0.05% cream applied daily was compared to its vehicle with regards to epidermal, basal, spinous differentiation markers and dendri...
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
1998-01-01T00:00:00Z.
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| Summary: | Fifteen very fair women with mild to moderate photoaging in there 60â€s were tested by doubled blind immunohistological study. Tretinoin 0.05% cream applied daily was compared to its vehicle with regards to epidermal, basal, spinous differentiation markers and dendritic cells (Langerhanâ€s and melariocyte). In comparison with the control skin, tretinoin-treated skin showed the following changes: 1. From atrophy to normalization or hyperplasia of horny and prickle cell layers,2. Granular layer was normal to hypertrophied, 3. Basal cells were well-stained and thicker, 4. Basement membrane was thicker to normal in appearance and 5. Dendritic cells were increased in number (Langerhanâ€s). These results demonstrated a decelerating effect of tretinoin on the time clock of photoaging. |
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| Item Description: | 0019-5154 1998-3611 |