Fabry disease exacerbates renal interstitial fibrosis after unilateral ureteral obstruction via impaired autophagy and enhanced apoptosis

• Main Authors: Sungjin Chung (Author), Mina Son (Author), Yura Chae (Author), Songhee Oh (Author), Eun Sil Koh (Author), Yong Kyun Kim (Author), Seok Joon Shin (Author), Cheol Whee Park (Author), Sung-Chul Jung (Author), Ho-Shik Kim (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Fabry disease is a rare X-linked genetic lysosomal disorder caused by mutations in the GLA gene encoding alpha-galactosidase A. Despite some data showing that profibrotic and proinflammatory cytokines and oxidative stress could be involved in Fabry disease-related renal injury, the pathog...