ARTERIAL STIFFNESS PARAMETERS IN PATIENTS WITH MODERATE/HIGH CARDIOVASCULAR RISK DURING LISINOPRIL AND SIMVASTATIN TREATMENT

• Main Authors: V. N. Isakova (Author), O. G. Garbuzova (Author), E. V. Klinkova (Author), E. V. Bandurko (Author)
• Format: Book
• Published: Столичная издательская компания, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1819-6446; 2225-3653; 10.20996/1819-6446-2009-5-3-14-18
• Keywords: non-invasive arteriography; pulse wave velocity; lisinopril; simvastatin; Therapeutics. Pharmacology; RM1-950; Diseases of the circulatory (Cardiovascular) system; RC666-701
• Source: Рациональная фармакотерапия в кардиологии, Vol 5, Iss 3, Pp 14-18 (2016)

Aim. To evaluate parameters of arterial stiffness by non-invasive arteriography in patients with moderate/high cardiovascular risk receiving lisinopril and simvastatin.Material and methods. 20 patients (aged 50-55 y.o.) with arterial hypertension of the 1st degree and dislipidemia are included in the study. All patients had pulse wave velocity (PWV) ≥ 10 m/s and/or the corrected index of pulse wave augmentation (AI × 80) ≥ -10% according to non-invasive arteriography data; and moderate-high cardiovascular risk (≥ 3%). Patients received therapy with lisinopril and simvastatin. Blood pressure (BP) levels and lipid profiles were assessed before therapy and in 1, 2, 6 and 12 month of the observation. Non-invasive arteriography was performed before therapy and in 2, 6 and 12 months later.Results. BP target levels were reached within 1 month of treatment as well as improvement of lipid profile was reached within 2 months in majority of the patients. Reference PWV and AI were reached in 85,7% of patients within one year of treatment.Conclusion. Arterial stiffness parameters help to evaluate cardiovascular risk changes accurately as the results of treatment.