<it>TCF7L2 </it>and therapeutic response to sulfonylureas in patients with type 2 diabetes
<p>Abstract</p> <p>Background</p> <p>Variants in the <it>TCF7L2 </it>have been shown to be associated with an increased risk for type 2 diabetes (T2D). Since the association with diabetes could be explained by effects on insulin secretion, we investigated wh...
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| Main Authors: | , , , , |
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| Format: | Book |
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BMC,
2011-02-01T00:00:00Z.
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Variants in the <it>TCF7L2 </it>have been shown to be associated with an increased risk for type 2 diabetes (T2D). Since the association with diabetes could be explained by effects on insulin secretion, we investigated whether patients with diabetes risk alleles at rs7903146 might have an altered hypoglycaemic response to sulfonylureas (SUs).</p> <p>Methods</p> <p>We recruited 189 patients with T2D being treated with SUs and determined the rs7903146 diabetes risk genotype. We used a logistic regression with secondary SU failure defined as an A1C ≥7.0% after 6 months of SU treatment.</p> <p>Results</p> <p>In univariate regression analyses, <it>TCF7L2 </it>genotype was the only predictor of SU treatment failure. The rs7903146 T allele was significantly more frequent in the group of patients who failed to respond to SU (36%) than in the control group (26%) [<it>P </it>= <it>0.046; </it>odds ratio (OR): 1.57 (1.01-2.45) in an additive mode of inheritance].</p> <p>Conclusions</p> <p>Our data suggest that patients with diabetes risk alleles in <it>TCF7L2 </it>have an altered hypoglycaemic response to SUs resulting in earlier secondary failure.</p> |
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| Item Description: | 10.1186/1471-2350-12-30 1471-2350 |