Nanocrytals-Mediated Oral Drug Delivery: Enhanced Bioavailability of Amiodarone

• Main Authors: Anum Munir Awan (Author), Arshad Farid (Author), Shefaat Ullah Shah (Author), Dildar Khan (Author), Fiza Ur Rehman (Author), Muhammad Junaid Dar (Author), Tayyaba Iftikhar (Author), Shakira Ghazanfar (Author), Charis M. Galanakis (Author), Abdulhakeem S. Alamri (Author), Syed Mohammed Basheeruddin Asdaq (Author), Kifayat Ullah Shah (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to improve the saturation solubility, dissolution profile and oral bioavailability of amiodarone hydrochloride (AMH), a highly lipophilic drug. Stabilizer (Pluronic F-127)-coated AMH nanocrystals (AMH-NCs) were developed by a combination of antisolvent precipitation and hom...