Splice‐switch oligonucleotide‐based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC‐driven hepatocellular carcinoma
Abstract Deregulation of MYC is among the most frequent oncogenic drivers in hepatocellular carcinoma (HCC). Unfortunately, the clinical success of MYC‐targeted therapies is limited. Synthetic lethality offers an alternative therapeutic strategy by leveraging on vulnerabilities in tumors with MYC de...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2023-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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