Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy
Immunotherapy combined with effective therapeutics such as chemotherapy and photodynamic therapy have been shown to be a successful strategy to activate anti-tumor immune responses for improved anticancer treatment. However, developing multifunctional biodegradable, biocompatible, low-toxic but high...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2023-02-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_77dc90fe0c24431aa349433fff55496d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Jianjun Cheng |e author |
| 700 | 1 | 0 | |a Haitian Zhao |e author |
| 700 | 1 | 0 | |a Bin Li |e author |
| 700 | 1 | 0 | |a Hua Zhang |e author |
| 700 | 1 | 0 | |a Qianyu Zhao |e author |
| 700 | 1 | 0 | |a Shiyao Fu |e author |
| 700 | 1 | 0 | |a Ying Han |e author |
| 700 | 1 | 0 | |a Weihong Lu |e author |
| 700 | 1 | 0 | |a Jiahua Shi |e author |
| 700 | 1 | 0 | |a Xin Yang |e author |
| 245 | 0 | 0 | |a Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy |
| 260 | |b Elsevier, |c 2023-02-01T00:00:00Z. | ||
| 500 | |a 2211-3835 | ||
| 500 | |a 10.1016/j.apsb.2022.06.008 | ||
| 520 | |a Immunotherapy combined with effective therapeutics such as chemotherapy and photodynamic therapy have been shown to be a successful strategy to activate anti-tumor immune responses for improved anticancer treatment. However, developing multifunctional biodegradable, biocompatible, low-toxic but highly efficient, and clinically available transformed nano-immunostimulants remains a challenge and is in great demand. Herein, we report and design of a novel carrier-free photo-chemotherapeutic nano-prodrug COS-BA/Ce6 NPs by combining three multifunctional components-a self-assembled natural small molecule betulinic acid (BA), a water-soluble chitosan oligosaccharide (COS), and a low toxic photosensitizer chlorin e6 (Ce6)-to augment the antitumor efficacy of the immune adjuvant anti-PD-L1-mediated cancer immunotherapy. We show that the designed nanodrugs harbored a smart and distinctive "dormancy" characteristic in chemotherapeutic effect with desired lower cytotoxicity, and multiple favorable therapeutic features including improved 1O2 generation induced by the reduced energy gap of Ce6, pH-responsiveness, good biodegradability, and biocompatibility, ensuring a highly efficient, synergistic photochemotherapy. Moreover, when combined with anti-PD-L1 therapy, both nano-coassembly based chemotherapy and chemotherapy/photodynamic therapy (PDT) could effectively activate antitumor immunity when treating primary or distant tumors, opening up potentially attractive possibilities for clinical immunotherapy. | ||
| 546 | |a EN | ||
| 690 | |a Cancer immunotherapy | ||
| 690 | |a Nano-immunostimulants | ||
| 690 | |a Chemotherapeutic dormancy | ||
| 690 | |a Pro-drug | ||
| 690 | |a Self-assembly | ||
| 690 | |a Natural small molecule | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 879-896 (2023) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2211383522002738 | |
| 787 | 0 | |n https://doaj.org/toc/2211-3835 | |
| 856 | 4 | 1 | |u https://doaj.org/article/77dc90fe0c24431aa349433fff55496d |z Connect to this object online. |