Protective Effect of Apple Cider Vinegar in Hydroxyurea Treated Mice

• Main Authors: R.S. Ayoub (Author), T.A. Al-Sandok (Author), S.W. Yousif (Author)
• Format: Book
• Published: College of Education for Pure Sciences, 2005-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Bone marrow depression is the mo:.it serious dose limiting toxicity of hydroxy urea . Natural apple cider vinegar in supposed to have both chemo-proteotive and myelo -stimulatory effects .<br /> In this study , hydroxy urea at a dose of 80mg/kg/day orally produced significant depression of red blood cell, adecrease in white<br /> blood cells and platelets in mice . 20mg/kg/day of apple cider vinegar seven days after hydroxy urea was administered produced no improvement in red blood cells and white blood cells and platelets counts.<br /> The administration of apple cider vinegar with hydroxy urea produced significant (P<0.05) increase in red blood cells and white blood cells while platelets not recovered to normal .<br /> The effect of hydroxy urea in mice on protein was observed as depressant effect significantly (P<0,05) on total protein adecrease in albumin and globulin .<br /> The administration of apple cider vinegar seven days after hydroxy urea produced no significant effect on globulin and albumin , yet the total protein increased but not significantly .<br /> The administration of apple cider vinegar at the same time with hydroxy urea significantly increase total protein and globulin , while no change on albumin level .<br /> The results in this study indicate that apple cider vinegar has a protective effect on bone marrow from depressive effect of cyto toxic drug hydroxyurea .

Item Description

1812-125X
2664-2530
10.33899/edusj.2005.81313