Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds
A series of new coumarin containing compounds were synthesized from 4-bromomethylcoumarin derivatives 2a, b and different heteroaromatic systems 4a-e, 6a-d, 8, 10 via methylene thiolinker. Twenty-four compounds were screened biologically against two human tumor cell lines, breast carcinoma MCF-7 and...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2017-09-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_7813a751f15448ce8f7c091d867077e8 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shaimaa A. Morsy |e author |
| 700 | 1 | 0 | |a Abdelbasset A. Farahat |e author |
| 700 | 1 | 0 | |a Magda N.A. Nasr |e author |
| 700 | 1 | 0 | |a Atif S. Tantawy |e author |
| 245 | 0 | 0 | |a Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds |
| 260 | |b Elsevier, |c 2017-09-01T00:00:00Z. | ||
| 500 | |a 1319-0164 | ||
| 500 | |a 10.1016/j.jsps.2017.02.003 | ||
| 520 | |a A series of new coumarin containing compounds were synthesized from 4-bromomethylcoumarin derivatives 2a, b and different heteroaromatic systems 4a-e, 6a-d, 8, 10 via methylene thiolinker. Twenty-four compounds were screened biologically against two human tumor cell lines, breast carcinoma MCF-7 and hepatocellular carcinoma HePG-2, at the national cancer institute, Cairo, Egypt using 5-fluorouracil as standard drug. Compounds 5h, 7d, 7h, 9a, 13a and 13d showed strong activity against both MCF-7 and HepG-2 cell lines with being compound 13a is the most active with IC50 values of 5.5 µg/ml and 6.9 µg/ml respectively. Docking was performed with protein 1KE9 to study the binding mode of the designed compounds. | ||
| 546 | |a EN | ||
| 690 | |a Coumarin | ||
| 690 | |a Triazole | ||
| 690 | |a Oxadiazole | ||
| 690 | |a Thiadiazole | ||
| 690 | |a Anticancer | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Saudi Pharmaceutical Journal, Vol 25, Iss 6, Pp 873-883 (2017) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1319016417300257 | |
| 787 | 0 | |n https://doaj.org/toc/1319-0164 | |
| 856 | 4 | 1 | |u https://doaj.org/article/7813a751f15448ce8f7c091d867077e8 |z Connect to this object online. |