Amyloid-β Induces Cdh1-Mediated Rock2 Stabilization Causing Neurodegeneration

• Main Authors: Rebeca Lapresa (Author), Jesus Agulla (Author), Sonia Gonzalez-Guerrero (Author), Juan P. Bolaños (Author), Angeles Almeida (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, which is causally related to the accumulation of abnormally folded amyloid-β (Aβ) peptide and hyperphosphorylated tau protein aggregates. The dendritic spine regulator Rho protein kinase 2 (...