Evaluation of the pharmacokinetics of trazpiroben (TAK‐906) in the presence and absence of the proton pump inhibitor esomeprazole

• Main Authors: Jatinder Kaur Mukker (Author), George Dukes (Author), Lisi Wang (Author), Susanna Huh (Author), Polyna Khudyakov (Author), Mitsuhiro Nishihara (Author), Chunlin Chen (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Trazpiroben, a dopamine D2/D3 receptor antagonist under development to treat gastroparesis, displays decreasing solubility with increasing pH. This single‐sequence, open‐label, two‐period, crossover study evaluated the effect of esomeprazole, a proton pump inhibitor that raises gastric pH,...