Phosphodiesterase 10A Is a Mediator of Osteogenic Differentiation and Mechanotransduction in Bone Marrow-Derived Mesenchymal Stromal Cells

• Main Authors: Sigrid Müller-Deubert (Author), Carolin Ege (Author), Melanie Krug (Author), Jutta Meißner-Weigl (Author), Maximilian Rudert (Author), Oliver Bischof (Author), Franz Jakob (Author), Regina Ebert (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone marrow-derived mesenchymal stromal cells (hMSCs) are capable of differentiating into the osteogenic lineage, and for osteogenic differentiation, mechanical loading is a relevant stimulus. Mechanotransduction leads to the formation of second messengers such as cAMP, cGMP, or Ca2+ influx resultin...