The anti-diabetic and antioxidant effects of a combination of Commiphora mukul, Commiphora myrrha and Terminalia chebula in diabetic rats

• Main Authors: Reyhaneh Sotoudeh (Author), Mousa- (Author), Zahra Gholamnezhad (Author), Azita Aghaee (Author)
• Format: Knjiga
• Izdano: Mashhad University of Medical Sciences, 2019-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Izvleček

<strong><span style="font-size: medium;">Objective:</span></strong><span style="font-size: medium;"> Effects of <em>Commiphora mukul</em></span><span style="font-size: medium;"> and </span><em><span style="font-size: medium;">Commiphora myrrha</span></em><span style="font-size: medium;"> ethanolic extracts and </span><em><span style="font-size: medium;">Terminalia chebula</span></em><span style="font-size: medium;"> hydro-ethanolic extract combination were evaluated in streptozotocin (STZ)-induced diabetic rats. </span><br /> <strong><span style="font-size: medium;">Materials and Methods:</span></strong><span style="font-size: medium;"> Male Wistar rats (n=48) were randomly assigned into: control; diabetic; diabetic+metformin (300 mg/kg); diabetic+dose 1 of herbal combination (438 mg/kg of <em>C. mukul</em></span><span style="font-size: medium;">+214 mg/kg of </span><em><span style="font-size: medium;">C. myrrha</span></em><span style="font-size: medium;">+857 mg/kg of </span><em><span style="font-size: medium;">T. chebula</span></em><span style="font-size: medium;">); diabetic+dose 2 (642 mg/kg of </span><em><span style="font-size: medium;">C. mukul</span></em><span style="font-size: medium;">+214 mg/kg of </span><em><span style="font-size: medium;">C. myrrha</span></em><span style="font-size: medium;">+642 mg/kg of </span><em><span style="font-size: medium;">T. chebula</span></em><span style="font-size: medium;">); and diabetic+dose 3 (857 mg/kg of </span><em><span style="font-size: medium;">C. mukul</span></em><span style="font-size: medium;">+438 mg/kg of </span><em><span style="font-size: medium;">C. myrrha</span></em><span style="font-size: medium;">+1714 mg/kg t of </span><em><span style="font-size: medium;">T. chebula</span></em><span style="font-size: medium;">). All treatments were given orally by gavage. Diabetes was induced by STZ (60 mg/kg, i.p.). At the end of study (day 28), blood glucose, insulin and lipid profile; as well as hepatic malondialdehyde (MDA) and thiol content, and superoxide dismutase (SOD) and catalase (CAT) activities were determined. </span><br /> <span style="font-size: medium;"><strong>Results:</strong> In diabetic rats, plasma glucose, triglycerides (TG), total cholesterol (TC), and LDL-C, as well as hepatic MDA levels were elevated but plasma HDL-C and insulin, and hepatic thiol content and SOD and CAT activities were reduced compared to control (p<0.01-p<0.001). In diabetic+dose 3, plasma TC, TG, and LDL-C and hepatic MDA level decreased (p<0.001), while plasma HDL-C and insulin, and hepatic thiol content, and SOD and CAT activities increased compared to diabetic (p<0.01-p<0.001). Treatment with dose 1 and 2 improved such abnormalities in diabetic rats except for insulin level (p<0.05-p<0.001). The herbal combination effects were comparable to those of metformin. Metformin did not significantly change serum insulin and HDL-C levels, and hepatic SOD activity; however, serum levels of TC, TG, and LDL-C, as well as hepatic MDA levels, thiol content and CAT activity were improved compared to diabetic (p<0.05-p<0.001). </span><br /> <span style="font-size: medium;"><strong>Conclusion:</strong> These results indicate that this herbal combination acts as an anti-diabetic, antioxidant and hypolipidemic agent and it may be suggested as a beneficial remedy for diabetic patients.</span><br /> <br /> <strong><br clear="all" /> </strong>

Opis knjige/članka

2228-7930
2228-7949
10.22038/ajp.2019.12721