Flavanols from the Camellia sinensis var. assamica and their hypoglycemic and hypolipidemic activities
α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia.To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named (-)-epicatechin-3-O-(Z)-coumarate (1), a...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2017-05-01T00:00:00Z.
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| Summary: | α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia.To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named (-)-epicatechin-3-O-(Z)-coumarate (1), and 16 known analogs (217) were isolated from the aqueous extract of the pu-erh tea. Their structures were determined by spectroscopic and chemical methods. Furthermore, the water extract of pu-erh tea and its fractions exhibited inhibitory activities against α-glucosidases and lipases in vitro; compound 15 showed moderate inhibitory effect against sucrase with an IC50 value of 32.5 μmol/L and significant inhibitory effect against maltase with an IC50 value of 1.3 μmol/L. Compounds 8, 10, 11 and 15 displayed moderate activity against a lipase with IC50 values of 16.0, 13.6, 19.8, and 13.3 μmol/L, respectively. |
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| Item Description: | 2211-3835 2211-3843 10.1016/j.apsb.2016.12.007 |