High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression

• Main Authors: Nadine Unterwalder (Author), Christian Meisel (Author), Konstantinos Savvatis (Author), Ben Hammoud (Author), Christina Fotopoulou (Author), Hans-Dieter Volk (Author), Petra Reinke (Author), Joerg C. Schefold (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. High-mobility group box-1 (HMGB-1) protein is released during "late sepsis" by activated monocytes. We investigated whether systemic HMGB-1 levels are associated with indices of monocytic activation/function in patients with sepsis-induced immunosuppression. Methodology. 36 pat...