Prevalence and genotypic relatedness of carbapenem resistance among multidrug-resistant <it>P. aeruginosa</it> in tertiary hospitals across Thailand
<p>Abstract</p> <p>Background</p> <p>Increased infection caused by multidrug resistant (MDR) <it>Pseudomonas aeruginosa</it> has raised awareness of the resistance situation worldwide. Carbapenem resistance among MDR (CR-MDR) <it>P. aeruginosa</it&g...
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| Main Authors: | , , , , |
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| Format: | Book |
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BMC,
2012-09-01T00:00:00Z.
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Increased infection caused by multidrug resistant (MDR) <it>Pseudomonas aeruginosa</it> has raised awareness of the resistance situation worldwide. Carbapenem resistance among MDR (CR-MDR) <it>P. aeruginosa</it> has become a serious life-threatening problem due to the limited therapeutic options. Therefore, the objectives of this study were to determine the prevalence, the antibiotic susceptibility patterns and the relatedness of CR-MDR <it>P. aeruginosa</it> in tertiary hospitals across Thailand.</p> <p>Methods</p> <p>MDR <it>P. aeruginosa</it> from eight tertiary hospitals across Thailand were collected from 2007-2009. Susceptibility of <it>P. aeruginosa</it> clinical isolates was determined according to the Clinical and Laboratory Standards Institute guideline. Selected CR-MDR <it>P. aeruginosa</it> isolates were genetically analyzed by pulsed-field gel electrophoresis.</p> <p>Results</p> <p>About 261 clinical isolates were identified as MDR <it>P. aeruginosa</it> and approximately 71.65% were found to be CR-MDR <it>P. aeruginosa.</it> The result showed that the meropenem resistance rate was the highest reaching over 50% in every hospitals. Additionally, the type of hospitals was a major factor affecting the resistance rate, as demonstrated by significantly higher CR-MDR rates among university and regional hospitals. The fingerprinting map identified 107 clones with at least 95% similarity. Only 4 clones were detected in more than one hospital.</p> <p>Conclusions</p> <p>Although the antibiotic resistance rate was high, the spreading of CR-MDR was found locally. Specific strains of CR-MDR did not commonly spread from one hospital to another. Importantly, clonal dissemination ratio indicated limited intra-hospital transmission in Thailand.</p> |
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| Item Description: | 10.1186/1476-0711-11-25 1476-0711 |