iNKT Cell Activation Exacerbates the Development of Huntington's Disease in R6/2 Transgenic Mice

• Main Authors: Hyun Jung Park (Author), Sung Won Lee (Author), Wooseok Im (Author), Manho Kim (Author), Luc Van Kaer (Author), Seokmann Hong (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2019-01-01T00:00:00Z.
• Fag: article
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Huntington's disease (HD) is an inherited neurodegenerative disorder which is caused by a mutation of the huntingtin (HTT) gene. Although the pathogenesis of HD has been associated with inflammatory responses, if and how the immune system contributes to the onset of HD is largely unknown. Invar...