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Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity

Background: As drug-metabolizing enzyme activities are affected by a variety of factors, such as drug-drug interactions, a method to evaluate drug-metabolizing enzyme activities in real time is needed. In this study, we developed a novel SPECT imaging probe for evaluation of hepatic CYP2D activity.M...

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Main Authors: Asuka Mizutani (Author), Masato Kobayashi (Author), Kodai Nishi (Author), Ken-ichi Fujita (Author), Kotaro Takahashi (Author), Yuka Muranaka (Author), Kakeru Sato (Author), Masanori Kitamura (Author), Chie Suzuki (Author), Ryuichi Nishii (Author), Naoto Shikano (Author), Yasuhiro Magata (Author), Yasushi Ishida (Author), Munetaka Kunishima (Author), Kazuki Fukuchi (Author), Keiichi Kawai (Author)
Format: Book
Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
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