Effect of the main metabolite of afobazole M-11 on acute exudative inflammation and visceral pain in mice
In the model of peritonitis in mice induced by intraperitoneal injection of acetic acid the main metabolite of afobazole M-11 at doses of 1, 5 and 10 mg/kg per os reduces the intensity of the exudative stage of inflammation, but at doses of 20 and 40 mg/kg it exhibits no anti-inflammatory activity....
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| Main Authors: | , |
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| Format: | Book |
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LLC "Publisher OKI",
2016-03-01T00:00:00Z.
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| Summary: | In the model of peritonitis in mice induced by intraperitoneal injection of acetic acid the main metabolite of afobazole M-11 at doses of 1, 5 and 10 mg/kg per os reduces the intensity of the exudative stage of inflammation, but at doses of 20 and 40 mg/kg it exhibits no anti-inflammatory activity. The anti-inflammatory activity of M-11 at doses of 1, 5 and 10 mg/kg is less pronounced compared with diclofenac sodium 10 mg/kg. Evaluation of the influence of M-11 on visceral pain induced by inflammation demonstrated that the main metabolite of afobazole does not exhibit analgesic activity. |
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| Item Description: | 2587-7836 2686-8830 |