Stability-indicating HPLC-DAD method for the determination of empagliflozin
Abstract Background A stability-indicating RP-HPLC method was developed and validated for the estimation of empagliflozin drug and its tablet dosage form using a DAD detector. The mobile phase consisted of methanol/acetonitrile/0.1%OPA (75:20:5). The peak was observed at 2.54 min using 222.0 nm abso...
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2021-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_79d73ec74f2545a78e34094e1510b0b0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shilpi Pathak |e author |
| 700 | 1 | 0 | |a Pradeep Mishra |e author |
| 245 | 0 | 0 | |a Stability-indicating HPLC-DAD method for the determination of empagliflozin |
| 260 | |b SpringerOpen, |c 2021-08-01T00:00:00Z. | ||
| 500 | |a 10.1186/s43094-021-00329-w | ||
| 500 | |a 2314-7253 | ||
| 520 | |a Abstract Background A stability-indicating RP-HPLC method was developed and validated for the estimation of empagliflozin drug and its tablet dosage form using a DAD detector. The mobile phase consisted of methanol/acetonitrile/0.1%OPA (75:20:5). The peak was observed at 2.54 min using 222.0 nm absorption maxima. Results Calibration curve plot was found within the range of 10-50 µg/mL. The coefficient of determination (R 2) was found to be 0.9990. Forced degradation studies were performed for the empagliflozin in various conditions, and the results were calculated as %RSD values and were found to be within the limits. Conclusion The method was validated as per ICH guidelines with respect to all validation parameters. | ||
| 546 | |a EN | ||
| 690 | |a Empagliflozin | ||
| 690 | |a RP-HPLC | ||
| 690 | |a Stress study | ||
| 690 | |a Validation | ||
| 690 | |a DAD detector | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-8 (2021) | |
| 787 | 0 | |n https://doi.org/10.1186/s43094-021-00329-w | |
| 787 | 0 | |n https://doaj.org/toc/2314-7253 | |
| 856 | 4 | 1 | |u https://doaj.org/article/79d73ec74f2545a78e34094e1510b0b0 |z Connect to this object online. |