Validation of a search strategy for randomized clinical trials related to periodontitis

Abstract Background Systematic reviews, considered the gold standard for the assessment of scientific evidence, may present conflicting findings for the same clinical issue, and such dissent may be justified by the forms of elaboration of the electronic search strategy. This paper aims to validate a...

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Main Authors: Amanda Oliveira Lyrio (Author), Simone Seixas da Cruz (Author), Isaac Suzart Gomes-Filho (Author), Viviane Seixas Silva Silveira (Author), Elivan Silva Souza (Author), Josicélia Estrela Tuy Batista (Author), Ana Claudia Morais Godoy Figueiredo (Author), Mauricio Gomes Pereira (Author)
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Published: BMC, 2021-04-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Amanda Oliveira Lyrio  |e author 
700 1 0 |a Simone Seixas da Cruz  |e author 
700 1 0 |a Isaac Suzart Gomes-Filho  |e author 
700 1 0 |a Viviane Seixas Silva Silveira  |e author 
700 1 0 |a Elivan Silva Souza  |e author 
700 1 0 |a Josicélia Estrela Tuy Batista  |e author 
700 1 0 |a Ana Claudia Morais Godoy Figueiredo  |e author 
700 1 0 |a Mauricio Gomes Pereira  |e author 
245 0 0 |a Validation of a search strategy for randomized clinical trials related to periodontitis 
260 |b BMC,   |c 2021-04-01T00:00:00Z. 
500 |a 10.1186/s13690-021-00560-0 
500 |a 2049-3258 
520 |a Abstract Background Systematic reviews, considered the gold standard for the assessment of scientific evidence, may present conflicting findings for the same clinical issue, and such dissent may be justified by the forms of elaboration of the electronic search strategy. This paper aims to validate a search strategy to identify randomized clinical trials related to periodontitis. A gold standard reference set was developed to validate the identified clinical trials using the relative recall method. The choice of periodontitis is due to the fact that this disease has a high prevalence among chronic non-communicable diseases, is considered the second most common oral disease in the world, is associated with several health problems, such as cardiovascular diseases and diabetes, and, principally, has not been investigated sufficiently to prevent possible damages resulting from it. Methods A validation study was developed in MEDLINE/PubMed. In Stage 1, a methodological filter recommended by the Cochrane Collaboration to identify randomized clinical trials was applied. Stage 2 identified articles related only to periodontitis (gold standard reference set) from among the articles retrieved using the eligibility criteria. In Stage 3, a search statement for the retrieval of periodontitis-related articles was elaborated by experts. Stage 4 defined the proposed search strategy comprising of the combination of the search statement developed with the aforementioned methodological filter and subsequent application in MEDLINE/PubMed. The obtained data were analyzed using the set of articles identified in Stage 2, as the gold standard reference set. The following performance values were calculated - sensitivity, specificity, accuracy, and number needed to read - with their respective 95% confidence interval (95%CI). Results The search strategy under evaluation compared to the gold-standard showed a sensitivity of 93.2% (95%CI, 83.8-97.3), specificity of 99.9% (95%CI 99.8-99.9), and a precision of 77.5% (95%CI, 66.48-85.63). In addition, the number needed to read was 1.3. Conclusion According to the proposed methodological approach, the search strategy under evaluation performed well in the identification of randomized clinical trials related to periodontitis. 
546 |a EN 
690 |a Methodological studies 
690 |a Research design 
690 |a Systematic review 
690 |a Periodontitis 
690 |a Sensitivity 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Archives of Public Health, Vol 79, Iss 1, Pp 1-6 (2021) 
787 0 |n https://doi.org/10.1186/s13690-021-00560-0 
787 0 |n https://doaj.org/toc/2049-3258 
856 4 1 |u https://doaj.org/article/7a2cb7cc887f45dbaa26d2a34e1658d6  |z Connect to this object online.