Time to decide about risk-reducing mastectomy: A case series of <it>BRCA1/2 </it>gene mutation carriers

• Main Authors: Kelly Mary (Author), Bottorff Joan L (Author), McCullum Mary (Author), Kieffer Stephanie A (Author), Balneaves Lynda G (Author)
• Format: Book
• Published: BMC, 2007-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.1186/1472-6874-7-3; 1472-6874
• Keywords: Gynecology and obstetrics; RG1-991; Public aspects of medicine; RA1-1270
• Source: BMC Women's Health, Vol 7, Iss 1, p 3 (2007)

<p>Abstract</p> <p>Background</p> <p>The purpose of this research was to explore women's decision-making experiences related to the option of risk-reducing mastectomy (RM), using a case series of three women who are carriers of a <it>BRCA1/2 </it>gene mutation.</p> <p>Methods</p> <p>Data was collected in a pilot study that assessed the response of women to an information booklet about RM and decision-making support strategies. A detailed analysis of three women's descriptions of their decision-making processes and outcomes was conducted.</p> <p>Results</p> <p>All three women were carriers of a <it>BRCA1/2 </it>gene mutation and, although undecided, were leaning towards RM when initially assessed. Each woman reported a different RM decision outcome at last follow-up. Case #1 decided not to have RM, stating that RM was "too radical" and early detection methods were an effective strategy for dealing with breast cancer risk. Case #2 remained undecided about RM and, over time, she became less prepared to make a decision because she felt she did not have sufficient information about surgical effects. Case #3 had undergone RM by the time of her second follow-up interview and reported that she felt "a load off (her) mind now".</p> <p>Conclusion</p> <p>RM decision making may shift over time and require decision support over an extended period.</p>