Effects of 1α,25-Dihydroxyvitamin D₃ on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach

• Main Authors: Anusha Balla (Author), Yoo-Seong Jeong (Author), Hyo-Jung Kim (Author), Yun-Jong Lee (Author), Suk-Jae Chung (Author), Yoon-Jee Chae (Author), Han-Joo Maeng (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, possible changes in the expression of rat organic cationic transporters (rOCTs) and rat multidrug and toxin extrusion proteins (rMATEs) following treatment with 1α,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) were investigat...