Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats

• Main Authors: Eziuche Ugbogu (Author), Victor Chibueze Ude (Author), Iheanyichukwu Elekwa (Author), Uche Arunsi (Author), Chikezie Uche-Ikonne (Author), Chinedu Nwakanma (Author)
• Format: Book
• Published: Mashhad University of Medical Sciences, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2228-7930; 2228-7949; 10.22038/ajp.2018.27453.1982
• Keywords: Musa paradisiaca; acute toxicity; Sub-acute toxicity; Haematology; lipid profile; Histopathology; Therapeutics. Pharmacology; RM1-950
• Source: Avicenna Journal of Phytomedicine, Vol 8, Iss 6, Pp 478-487 (2018)

Objective: This study was conducted to assess the toxicity profile of the aqueous-fermented extract of Musa paradisiaca in rats. Materials and Methods: In acute toxicity test, the rats of different groups were orally administered with a single dose of 500, 1000, 2000 and 5000 mg/kg of fermented extract of M. paradisiaca. The rats were monitored for behavioral changes, toxicity signs and mortality. In sub-acute test, the rats were orally administered with fermented M. paradisiaca extract (200, 400 and 800 mg/kg/day) for 14 days. Haematological and serum biochemical parameters were evaluated and histopathological studies of the liver and kidney were done. The study was performed from June to July 2017. Results: Concerning the acute toxicity, no toxicity signs or death were recorded and an LD50 value of >5 g/kg for fermented extract of M. paradisiaca was observed. Regarding the sub-acute toxicity, ingestion of the fermented extract of M. paradisiacacaused no significant effects (p