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The Selective Serotonin 2A Receptor Antagonist Sarpogrelate Prevents Cardiac Hypertrophy and Systolic Dysfunction via Inhibition of the ERK1/2-GATA4 Signaling Pathway

Drug repositioning has recently emerged as a strategy for developing new treatments at low cost. In this study, we used a library of approved drugs to screen for compounds that suppress cardiomyocyte hypertrophy. We identified the antiplatelet drug sarpogrelate, a selective serotonin-2A (5-HT<sub...

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Main Authors: Kana Shimizu (Author), Yoichi Sunagawa (Author), Masafumi Funamoto (Author), Hiroki Honda (Author), Yasufumi Katanasaka (Author), Noriyuki Murai (Author), Yuto Kawase (Author), Yuta Hirako (Author), Takahiro Katagiri (Author), Harumi Yabe (Author), Satoshi Shimizu (Author), Nurmila Sari (Author), Hiromichi Wada (Author), Koji Hasegawa (Author), Tatsuya Morimoto (Author)
Format: Book
Published: MDPI AG, 2021-12-01T00:00:00Z.
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