Leveraging the Variability of Pharmacovigilance Disproportionality Analyses to Improve Signal Detection Performances

• Main Authors: Charles Khouri (Author), Thuy Nguyen (Author), Bruno Revol (Author), Marion Lepelley (Author), Antoine Pariente (Author), Matthieu Roustit (Author), Jean-Luc Cracowski (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: A plethora of methods and models of disproportionality analyses for safety surveillance have been developed to date without consensus nor a gold standard, leading to methodological heterogeneity and substantial variability in results. We hypothesized that this variability is inversely co...