Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

• المؤلفون الرئيسيون: Luana Abballe (مؤلف), Angela Mastronuzzi (مؤلف), Evelina Miele (مؤلف), Andrea Carai (مؤلف), Zein Mersini Besharat (مؤلف), Marta Moretti (مؤلف), Enrico De Smaele (مؤلف), Felice Giangaspero (مؤلف), Franco Locatelli (مؤلف), Elisabetta Ferretti (مؤلف), Agnese Po (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal express...