Enteric Polymer-Based Amorphous Solid Dispersions Enhance Oral Absorption of the Weakly Basic Drug Nintedanib via Stabilization of Supersaturation

• Hlavní autoři: Yuling Qin (Autor), Chuyao Xiao (Autor), Xiaoyue Li (Autor), Jiangeng Huang (Autor), Luqin Si (Autor), Minghui Sun (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2022-08-01T00:00:00Z.
• Témata: article
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The pH-induced crystallization of weakly basic drugs in the small intestine limits oral bioavailability. In this study, we investigated the solubilization and inhibitory effects on nintedanib in the presence of enteric polymers (HPMCAS LG, HPMCAS MG, Eudragit L100 55, and Eudragit L100). These polym...