The Relationship between RUNX3 Expression, Nursing Strategies and Nutritional Status in Elderly Patients with Advanced Gastric Cancer

Background: The aim of this study was to explore the relationship between nutritional status and expression of RUNX3 in gastric cancer cells and to investigate the effects of nursing strategies on the nutritional status of elderly patients with advanced gastric cancer. Methods: Forty-eight elderly p...

Full description

Saved in:
Bibliographic Details
Main Authors: Wen SONG (Author), Wenhui TENG (Author), Xinyan SHI (Author), Xiaozhen LIU (Author), Zheng CUI (Author), Zibin TIAN (Author)
Format: Book
Published: Tehran University of Medical Sciences, 2017-05-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_7b9f140b60eb40f5bd9d8cc0da0f7d30
042 |a dc 
100 1 0 |a Wen SONG  |e author 
700 1 0 |a Wenhui TENG  |e author 
700 1 0 |a Xinyan SHI  |e author 
700 1 0 |a Xiaozhen LIU  |e author 
700 1 0 |a Zheng CUI  |e author 
700 1 0 |a Zibin TIAN  |e author 
245 0 0 |a The Relationship between RUNX3 Expression, Nursing Strategies and Nutritional Status in Elderly Patients with Advanced Gastric Cancer 
260 |b Tehran University of Medical Sciences,   |c 2017-05-01T00:00:00Z. 
500 |a 2251-6085 
500 |a 2251-6093 
520 |a Background: The aim of this study was to explore the relationship between nutritional status and expression of RUNX3 in gastric cancer cells and to investigate the effects of nursing strategies on the nutritional status of elderly patients with advanced gastric cancer. Methods: Forty-eight elderly patients admitted at Affiliated Hospital of Qingdao University with advanced gastric cancer and 30 healthy controls were selected as subjects from 2014-15. The correlation between RNX3 gene expression and nutritional status of the gastric cancer patients was investigated. The patients with advanced gastric cancer who had low expression of RUNX3 gene were treated with holistic nursing while routine nursing was taken for those patients who had normal or high expression of RUNX3 gene. The nutritional statuses of these patients were evaluated after 3 months of nursing. After a follow-up of 1 year, the influence of different nursing methods on the survival time was evaluated. Results: Compared with normal gastric tissue, the expression of RUNX3 gene and protein in tissues of advanced gastric cancer were significantly decreased (P<0.01). Compared with patients with normal or high expressions of RUNX3, the nutritional statuses of advanced gastric cancer patients with low expressions of RUNX3 were lower (P<0.01). The nutritional statuses of patients with low expressions of RUNX3 were notably improved after holistic nursing, becoming equivalent to those with normal or high expression of RUNX3 who received routine nursing (P>0.05). The survival time of patients with low expression of RUNX3 who received holistic nursing were similar to patients with normal or high expression of RUNX3 who received routine nursing (P>0.05). Conclusion: RUNX3 is correlated with the occurrence and development of advanced gastric cancer. The low nutritional status of elderly advanced gastric cancer patients with low expressions of RUNX3 can be significantly enhanced by holistic nursing, thereby prolonging survival time. 
546 |a EN 
690 |a Nutritional status evaluation 
690 |a Advanced gastric cancer 
690 |a RUNX3 
690 |a Holistic nursing 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Iranian Journal of Public Health, Vol 46, Iss 6 (2017) 
787 0 |n https://ijph.tums.ac.ir/index.php/ijph/article/view/10078 
787 0 |n https://doaj.org/toc/2251-6085 
787 0 |n https://doaj.org/toc/2251-6093 
856 4 1 |u https://doaj.org/article/7b9f140b60eb40f5bd9d8cc0da0f7d30  |z Connect to this object online.