Galectin-3, histone deacetylases, and Hedgehog signaling: Possible convergent targets in schistosomiasis-induced liver fibrosis.

• Main Authors: Felipe Leite de Oliveira (Author), Katia Carneiro (Author), José Marques Brito (Author), Mariana Cabanel (Author), Jonathas Xavier Pereira (Author), Ligia de Almeida Paiva (Author), Wingkin Syn (Author), Neil C Henderson (Author), Marcia Cury El-Cheikh (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis affects approximately 240 million people in the world. Schistosoma mansoni eggs in the liver induce periportal fibrosis and hepatic failure driven by monocyte recruitment and macrophage activation, resulting in robust Th2 response. Here, we suggested a possible involvement of Galecti...