Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma

• Main Authors: Sushma Kalmodia (Author), Sowmya Parameswaran (Author), Kalaivani Ganapathy (Author), Wenrong Yang (Author), Colin J. Barrow (Author), Jagat R. Kanwar (Author), Kislay Roy (Author), Madavan Vasudevan (Author), Kirti Kulkarni (Author), Sailaja V. Elchuri (Author), Subramanian Krishnakumar (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of the interaction between p53 and HDM2 is an effective therapeutic strategy in cancers that harbor a wild-type p53 protein such as retinoblastoma (RB). Nanoparticle-based delivery of therapeutic molecules has been shown to be advantageous in localized delivery, including to the eye, by o...