Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug
Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B, and CYP3A families such as rifampicin. While assessing CYP2D6 activity under basal conditions and after pre-treatment with rifampicin in vivo, we surprisingl...
Saved in:
Main Authors: | Benjamin Berger (Author), Fabio Bachmann (Author), Urs Duthaler (Author), Stephan Krähenbühl (Author), Manuel Haschke (Author) |
---|---|
Format: | Book |
Published: |
Frontiers Media S.A.,
2018-07-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells
by: David Grünig, et al.
Published: (2018) -
Comparison Of Liver Cell Models Using The Basel Phenotyping Cocktail
by: Benjamin Berger, et al.
Published: (2016) -
Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study
by: Lea S Blaser, et al.
Published: (2021) -
Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans
by: Andreas Schittny, et al.
Published: (2021) -
Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis
by: Franziska Paech, et al.
Published: (2017)