Paradoxical Anticonvulsant Effect of Cefepime in the Pentylenetetrazole Model of Seizures in Rats
Many β-lactam antibiotics, including cephalosporins, may cause neurotoxic and proconvulsant effects. The main molecular mechanism of such effects is considered to be γ-aminobutyric acid type a (GABAa) receptor blockade, leading to the suppression of GABAergic inhibition and subsequent overexcitation...
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Main Authors: | Dmitry V. Amakhin (Author), Ilya V. Smolensky (Author), Elena B. Soboleva (Author), Aleksey V. Zaitsev (Author) |
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Format: | Book |
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MDPI AG,
2020-04-01T00:00:00Z.
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