Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

• Main Authors: Arne Hinrichs (Author), Barbara Kessler (Author), Mayuko Kurome (Author), Andreas Blutke (Author), Elisabeth Kemter (Author), Maren Bernau (Author), Armin M. Scholz (Author), Birgit Rathkolb (Author), Simone Renner (Author), Sebastian Bultmann (Author), Heinrich Leonhardt (Author), Martin Hrabĕ de Angelis (Author), Hiroshi Nagashima (Author), Andreas Hoeflich (Author), Werner F. Blum (Author), Martin Bidlingmaier (Author), Rüdiger Wanke (Author), Maik Dahlhoff (Author), Eckhard Wolf (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were generated and characterized. Methods: CRISPR/Cas9 tech...