GLP-1 Analogue Liraglutide Enhances SP-A Expression in LPS-Induced Acute Lung Injury through the TTF-1 Signaling Pathway

• Main Authors: Tao Zhu (Author), Changyi Li (Author), Xue Zhang (Author), Chunyan Ye (Author), Shuo Tang (Author), Wei Zhang (Author), Jiayang Sun (Author), Niwen Huang (Author), Fuqiang Wen (Author), Daoxin Wang (Author), Huojin Deng (Author), Jing He (Author), Di Qi (Author), Wang Deng (Author), Tao Yang (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reduction of pulmonary surfactant (PS) is essential for decreased pulmonary compliance and edema in acute lung injury (ALI). Thyroid transcription factor-1 (TTF-1) plays a major role in the regulation of surfactant protein-A (SP-A), the most abundant protein component of PS. Simultaneously, the...