Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

• Main Authors: Lisa M. Nicholas (Author), Bérengère Valtat (Author), Anya Medina (Author), Lotta Andersson (Author), Mia Abels (Author), Inês G. Mollet (Author), Deepak Jain (Author), Lena Eliasson (Author), Nils Wierup (Author), Malin Fex (Author), Hindrik Mulder (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial transcription factor B2 (TFB2M) controls transcriptio...