Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway

• Main Authors: M. Rizwan Siddiqui (Author), Narsa M. Reddy (Author), Hafeez M. Faridi (Author), Mohd Shahid (Author), Thomas P. Shanley (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Microvascular endothelial hyperpermeability is an earliest pathological hallmark in Acute Lung Injury (ALI), which progressively leads to Acute Respiratory Distress Syndrome (ARDS). Recently, vascular protective and anti-inflammatory effect of metformin, irrespective of glycemic control,...