Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital

• Main Authors: Giancarlo Pérez-Lazo (Author), Susan Abarca-Salazar (Author), Renata Lovón (Author), Rocío Rojas (Author), José Ballena-López (Author), Adriana Morales-Moreno (Author), Wilfredo Flores-Paredes (Author), Berenice Arenas-Ramírez (Author), Luis Ricardo Illescas (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

A descriptive design was carried out studying the correlation between antimicrobial consumption and resistance profiles of ESKAPE pathogens (<i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> spp.) in a Peruvian hospital, including the surgical, clinical areas and the intensive care unit (ICU) during the time period between 2015 and 2018. There was a significant correlation between using ceftazidime and the increase of carbapenem-resistant <i>Pseudomonas aeruginosa</i> isolations (R = 0.97; <i>p</i> < 0.05) and the resistance to piperacillin/tazobactam in <i>Enterobacter</i> spp. and ciprofloxacin usage (R = 0.97; <i>p</i> < 0.05) in the medical wards. The <i>Pseudomonas aeruginosa</i> resistance to piperacillin/tazobactam and amikacin in the intensive care unit (ICU) had a significant reduction from 2015 to 2018 (67% vs. 28.6%, 65% vs. 34.9%, <i>p</i> < 0.001). These findings give valuable information about the rates and dynamics in the relationship between antibiotic usage and antimicrobial resistance patterns in a Peruvian hospital and reinforce the need for continuous support and assessment of antimicrobial stewardship strategies, including microbiological indicators and antimicrobial consumption patterns.

Item Description

10.3390/antibiotics10101221
2079-6382