Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients

• Main Authors: Liang Ding (Author), Fang‐bin Zhang (Author), Hui Liu (Author), Xiang Gao (Author), Hui‐chang Bi (Author), Ling Huang (Author), Xue‐ding Wang (Author), Bai‐li Chen (Author), Yu Zhang (Author), Chuanzhu Lv (Author), Pin‐jin Hu (Author), Min Huang (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Xanthine oxidase (XO) competes with thiopurine S‐methyltransferase (TPMT) and hypoxanthine guanine phosphoribosyltransferase (HPRT) to metabolize azathioprine (AZA)/6‐mercaptopurine (6‐MP) in vivo. A retrospective investigation was performed to detect the activity of XO in thiopurine curati...