Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson's and other brain diseases
Neuronal expression of major histocompatibility complex I (MHC-I) has been implicated in developmental synaptic plasticity and axonal regeneration in the central nervous system (CNS), but recent findings demonstrate that constitutive neuronal MHC-I can also be involved in neurodegenerative diseases...
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| Format: | Book |
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Frontiers Media S.A.,
2014-10-01T00:00:00Z.
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| 001 | doaj_7d10d50f07aa42e9b1ef8c44f54b53e0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Carolina eCebrián |e author |
| 700 | 1 | 0 | |a John D Loike |e author |
| 700 | 1 | 0 | |a David eSulzer |e author |
| 245 | 0 | 0 | |a Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson's and other brain diseases |
| 260 | |b Frontiers Media S.A., |c 2014-10-01T00:00:00Z. | ||
| 500 | |a 1662-5129 | ||
| 500 | |a 10.3389/fnana.2014.00114 | ||
| 520 | |a Neuronal expression of major histocompatibility complex I (MHC-I) has been implicated in developmental synaptic plasticity and axonal regeneration in the central nervous system (CNS), but recent findings demonstrate that constitutive neuronal MHC-I can also be involved in neurodegenerative diseases by playing a neuroinflammtory role. Recent reports demonstrate its expression in vitro and in human postmortem samples and support a role in neurodegeneration involving proinflammatory cytokines, activated microglia and increased cytosolic oxidative stress. MHC-I may be important for both normal development and pathogenesis of some CNS diseases including Parkinson's. | ||
| 546 | |a EN | ||
| 690 | |a Neurons | ||
| 690 | |a plasticity | ||
| 690 | |a neurodegeneration | ||
| 690 | |a Neuroinflammation | ||
| 690 | |a major histocompatibility complex class I | ||
| 690 | |a Neurosciences. Biological psychiatry. Neuropsychiatry | ||
| 690 | |a RC321-571 | ||
| 690 | |a Human anatomy | ||
| 690 | |a QM1-695 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Neuroanatomy, Vol 8 (2014) | |
| 787 | 0 | |n http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00114/full | |
| 787 | 0 | |n https://doaj.org/toc/1662-5129 | |
| 856 | 4 | 1 | |u https://doaj.org/article/7d10d50f07aa42e9b1ef8c44f54b53e0 |z Connect to this object online. |