Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress

• Main Authors: Chiara Lucchi (Author), Alessandro Codeluppi (Author), Monica Filaferro (Author), Giovanni Vitale (Author), Cecilia Rustichelli (Author), Rossella Avallone (Author), Jessica Mandrioli (Author), Giuseppe Biagini (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We obtained evidence that mouse BV2 microglia synthesize neurosteroids dynamically to modify neurosteroid levels in response to oxidative damage caused by rotenone. Here, we evaluated whether neurosteroids could be produced and altered in response to rotenone by the human microglial clone 3 (HMC3) c...